Dr. Luigi Montano UroAndrologo ospedaliero

Dr. Luigi Montano

Oliveto Citra (Salerno)

www.ecofoodfertility.it

Curriculum in breve

UroAndrologo ospedaliero, responsabile del primo Servizio Pubblico in Italia di Medicina dello Stile di Vita in UroAndrologia dell’ASL Salerno, esperto in Patologia Ambientale, Cofondatore della Società Europea di Medicina dello Stile di Vita con sede a Ginevra, di cui cura l'area UroAndrologica.
Da diversi anni il suo interesse è focalizzato sulla prevenzione della infertilità maschile, curando, in particolare, gli aspetti ambientali, alimentari e dello stile di vita. Ideatore e Coordinatore del Progetto di Ricerca EcoFoodFertility, (www.ecofoodfertility.it), uno studio multidisciplinare e multicentrico indipendente su scala europea che introduce un nuovo modello per la valutazione dell'impatto ambientale sulla salute umana per la prevenzione primaria delle popolazioni nelle aree a rischio, partendo dalla valutazione del liquido seminale quale precoce e sensibile marker di Salute Ambientale e Generale (Seme Sentinella). Ha all'attivo diverse pubblicazioni, alcuni capitoli di libri su riviste nazionali ed internazionali, numerose relazioni e keynote speaker in congressi nazionali ed internazionali con diversi premi e riconoscimenti, collabora per le ricerche sul rapporto Ambiente-Salute con diversi ricercatori del CNR, ISS, Università e centri di ricerche non solo italiani.

E’ co-fondatore dei Centri di Medicina Integrata della Riproduzione in Italia (MIR), il cui obiettivo è traslare i dati validati provenienti dalla ricerca clinica più recente nella pratica medica corrente, al fine di fornire i più moderni ed innovativi sistemi diagnostici per cure ed assistenza sempre più personalizzate in una visione di “One Health”.
E’ coordinatore della Rete Nazionale EcoFoodFertility, Rete per la Salvaguardia della Salute Ambientale nelle aree a rischio d'Italia (R.E.S.A.R.), una rete di ricercatori appartenenti a diverse discipline che collaborano al progetto nelle sue diverse articolazioni in campo non solo medico-scientifico. Ha all’attivo il coordinamento di diversi progetti su scala regionale e nazionale sul rapporto Ambiente/Salute ed in particolare un progetto multicentrico finanziato dal Ministero della Salute per la prevenzione dell'infertilità maschile nelle aree a forte pressione ambientale.

In linea generale, l’indirizzo dell'attività medico-scientifica è volto a proiettare la Fertilità in una dimensione di più ampia portata per la salvaguardia della Salute Pubblica, considerando la stessa come fondamentale Presidio di Prevenzione, non solo per le patologie riproduttive, ma anche per quelle cronico-degenerative dell'adulto e a difesa delle generazioni future.

Attività scientifica

1. EcoFoodFertility – Environmental and food impact assessment on male reproductive function. L.Montano, L. Iannuzzi, J. Rubes, C. Avolio, C. Pistos, A. Gatti, S. Raimondo, T.Notari, Andrology 2(Suppl.2):69, 2014
2. Valutazione dell’impatto ambientale sull’integrità del DNA nemaspermico mediante misurazione della proteina p53: dati preliminari (Progetto EcoFoodFertility).L. Montano, S. Raimondo, T. Notari, P. Bergamo, M. Rossi, D.Luongo, MG. Volpe, L. Iannuzzi Arch.Ital.Urol.Androl. 87 (Suppl.1):2, 2015
3. Evaluation of Enviornmental Impact on Sperm DNA integrity by Sperm Chromatin Dispersion Test ad p53 Elisa: Preliminary data. (EcoFoodFertility Project). L. Montano, T. Notari, S. Raimondo, P. Bergamo, M. Rossi, D. Luongo, MG Volpe, L. Iannuzzi. Reproductive Toxicology. Vol. 56: 20, 2015
4. Il liquido seminale: Marker precoce e sensibile di esposizione ambientale. Biomonitoraggio di elementi in traccia nel sangue e nel seme e relazione con la qualità seminale e lo stato RedOx (Progetto di Ricerca EcoFoodFertility). L.Montano, P. Bergamo, MG Volpe, S. Lorenzetti, A.Mantovani, T.Notari, E. Cocca, S. Cerullo,P. Cerino, M.Di Stasio. (Arch. Ital . Urol. Androl. Vol.88 (Suppl.1): 2, 2016
5. Environmental impact assessment on human fertility in males living in polluted areas of Campania Region by cytokinesis-block micronucleus assay and SCE test. V. Genualdo, A. Perucatti, A. Iannuzzi, C. Iorio, S.Ianuario, D. Incarnato, C.Rossetti, L.Montano, L. Iannuzzi. Clinical Cytogenetics, Mutagenesis. p.20, 50, 2016
6. Human semen as an early, sensitive biomarker of environmental exposure of healthy men living in highly polluted areas: a pilot biomonitoring study of trace elements in blood and semen and relationship with sperm quality and RedOx status. Paolo Bergamo, Maria Grazia Volpe, Stefano Lorenzetti, Alberto Mantovani Tiziana Notari, Ennio Cocca, Stefano Cerullo, Michele Di Stasio, Pellegrino Cerino and Luigi Montano*. Reproductive Toxicology.2016. 66:1-9.
7. Environmental pollutants: genetic damage and epigenetic changes in male germ cells. C.Vecoli, L.Montano, MG Andreassi. 2016. Environ Sci Pollut Res Int. 23(23):23339-48. doi 10.1007/s11356-016-7728-4
8. Effects of highly polluted environment on sperm telomere length: a pilot study. Cecilia Vecoli, Luigi Montano, Andrea Borghini, Tiziana Notari,Antonino Guglielmino, Antonella Mercuri, Stefano Turchi, Maria Grazia Andreassi. Int. J. Mol. Sci. 2017, 18, 1703; doi:10.3390/ijms18081703
9. Innovative environmental scanning electron microscopy observations of the human semen in the study of male infertility (preliminary data). Antonietta Gatti, Luigi Montano. Reproductive Toxicology Vol. 72:38, 2017 doi.org/10.1016/j.reprotox.2017.06.154
10. The role of human semen for assessing environmental impact on human health in risk areas: Novels and early biomarkers of environmental pollution. EcoFoodFertility project.Luigi Montano,Paolo Bergamo,Maria Grazia Andreassi,Cecilia Vecoli,Maria Grazia Volpe,Stefano Lorenzetti, Alberto Mantovani, Tiziana Notari. Reproductive Toxicology Vol. 72: 44-45. 2017 doi.org/10.1016/j.reprotox.2017.06.169
11. The role of the Mediterranean diet on sperm morphology in healthy men living in polluted area (EcoFoodFertility project).Luigi Montano, Giuseppe Porciello, Anna Crispo, Stefano Lorenzetti, Salvatore Raimondo, Stefania Ubaldi, Michela Caputo. Reproductive Toxicology Vol. 72: 45. 2017 doi.org/10.1016/j.reprotox.2017.06.170
12. Duplication of Yq- and proximal Yp-arms with deletion of almost all PAR1 (including SHOX) in a young man with non-obstructive azoospermia, short stature and skeletal defects. Dino Cancemi, Alessandra Iannuzzi, Angela Perucatti, Luigi Montano, Oronzo Capozzi, Carmine Spampanato, Maria Luisa Ventruto, Maria Urciuoli, Leopoldo Iannuzzi, Valerio Ventruto. Appl Genetics oct. 2017 DOI 10.1007/s13353-017-0412-7
13. Duplication of Yq- and proximal Yp-arms with deletion of almost all PAR1 (including SHOX) in a young man with non-obstructive azoospermia, short stature and skeletal defects. Dino Cancemi, Alessandra Iannuzzi, Angela Perucatti, Luigi Montano, Oronzo Capozzi, Carmine Spampanato, Maria Luisa Ventruto, Maria Urciuoli, Leopoldo Iannuzzi, Valerio Ventruto. Appl Genetics oct. 2017 DOI 10.1007/s13353-017-0412-7
14) EcoFoodFertility Project – from the crisis to the model –A new model for environmental impact assessment and for primary prevention in risk areas. Luigi Montano. 2017 Lambert Accademic publishing.
15) Rapid evaluation of free fatty acids concentration in edible hemp food chain using ATR-FTIR spectroscopy – Siano, F., Sorrentino, G., Paolucci, M., Montano, L., Volpe, M.G. 3rd Imekofoods October 1st- 4th 2017. Thessaloniky (Greece)
16) Human sperm cells sentinel of our living environment. Luigi Montano and Alberto Mantovani.Openaccessgovernment. Nov 2017. https://www.openaccessgovernment.org/human-sperm-cells-sentinel-of-our-living-environment/38889/
17) Sperm DNA fragmentation: an early and reliable marker of air pollution. Liana Bosco, Tiziana Notari, Giovanni Ruvolo, Maria C. Roccheri, Chiara Martino, Rosanna Chiappetta, Domenico Carone, Giosuè Lo Bosce, Laura Carrillo, Salvatore Raimondo, Antonino Guglielmino, Luigi Montano*.Environ Toxicol Pharmacol. 2018 Mar;58:243-249. doi: 10.1016/j.etap.2018.02.001 Epub 2018 Feb 7 .
18) The role of human semen as an early and reliable tool of environmental impact assessment on human health. Luigi Montano, Paolo Bergamo, Maria Grazia Andreassi, Stefano Lorenzetti. Full Chapter in Final Book Title & ISBN: Spermatozoa - Facts and Perspectives, " 978-1-78923-171-7. InTechOpen June 13th 2018 http://dx.doi.org/10.5772/intechopen.73231
19) ATR- FTIR spectroscopy application as a tool toderive biochemical signature differences inblood and human semen due to pollution.(Preliminary data). EcoFoodFertility Project. Luigi Montano, Maria Grazia Volpe, ,Costantina Barbarisi, Valentina De Vito. Reproductive Toxicology septemebre 2018 Volume 80, page 28. https://doi.org/10.1016/j.reprotox.2018.06.058
20) Potential role of p53 protein as a novel biomarker of sperm quality, able to predict the success of ART techniques. EcoFoodFertility Project. Luigi Montano, Salvatore Raimondo, Maria Cira Gentile, Tiziana Notari, Liana Bosco, Tommaso Gentile. Reproductive Toxicology Volume 80, September 2018 page 29. https://doi.org/10.1016/j.reprotox.2018.06.059
21) The role of synergic action between alpha-Tocoferol and lifestyle on reduction of p53 protein in human spermatozoa. (Preliminary data. EcoFoodFertility Project. Luigi Montano, Salvatore Raimondo, Maria Cira Gentile,Tiziana Notari Rosa Bifulco, Giuseppe Porciello, Tommaso Gentile. Reproductive Toxicology Volume 80, September 2018, Pages 29-30 https://doi.org/10.1016/j.reprotox.2018.06.060
22) Il Seme Sentinella – Un’antenna Epidemiologica nelle aree a rischio ambientali d’Italia a tutela della salute pubblica delle attuali e future generazioni. Luigi Montano. Io Uomo- Rivista quadrimestrale della Società Italiana di Andrologia, Novembre 2018, Pag. 12-13
23) Terra dei Fuochi, the starting point. The role of prevention and complementary medicine in the clinical practice. A. Del Buono, A. D’Orta, G, Tarro, P. Rossi, S. Papa, L.Iodice, A.Abbadessa, L. Montano, G. Portale, M. Beretta, R. Di Francia. World Cancer Global Journal, 2018; 5 (3) e 112, Pag. 1-7
24) Impatto sulla salute degli inquinanti indoor. Luigi Montano.Capitolo In “Inquinamento Indoor” a cura della Fondazione Veronesi. UTET Dicembre 2018
25) p53 protein evaluation on spermatozoa DNA in fertile and infertile males. Salvatore Raimondo, Tommaso Gentile, Mariacira Gentile, Alessia Morelli, Francesca Donnarumma, Felice Cuomo, Stefania De Filippo, Luigi Montano. J. Human Reproductive Science. Volume 12, June 2019, pages 114-121 DOI: 10.4103/jhrs.JHRS_170_18
26) Third party Reproduction: The Italian Society of Human Reproduction (SIRU) Consensus Meeting: p.782. A Guglielmino, P Viganò, L Montano, A Allegra, A Liprino, F Giacone, S Palini, A Paffoni, M Baldi, Z Donarelli, F Tomei, D Carone, E Papaleo, P Inaudi, E Somigliana. Human Reproduction 2019.
27) Human semen: Excellent bioaccumulator of volatile Organic compounds (VOCs). (EcoFoodFertility project). L. Montano, V. Longo, A. Forleo, S. Pappalardo, A. Ferramosca, P. Siciliano, S. Capone. European Urology Supplements, Volume 18, Issue 9, e3334 October 2019Volume 18, Issue 9, Page e3334 DOI: https://doi.org/10.1016/S1569-9056(19)33779-0
28) Sperm p53 concentration: A potential new biomarker for environmental pollution. Preliminary data. (EcoFoodFertility project). L. Montano, S. Raimondo, T. Notari, M. Gentile, L. Bosco, T. Gentile. European Urology Supplements, Volume 18, Issue 9, e3335. October 2019. DOI: https://doi.org/10.1016/S1569-9056(19)33780-7
29) Lifestyle, environmental exposures and male fertility in healthy young men in North Italy. C Zani, D Zani, F Donato, M Marullo, G C V Viola, S Lorenzetti, L Montano. European Journal of Public Health, Volume 29, Issue Supplement_4, November 2019, ckz186.459, https://doi.org/10.1093/eurpub/ckz186.459
30) Double Approach to Study VOC Composition in Biofluids of Young Men Living in the “Land of Fires” in Campania Region. V. Longo, A. Forleo, A. Ferramosca, P.Siciliano, S.Capone, S. Pappalardo, L. Montano. February 2020. Lecture Notes in Electrical Engineering 629:103-109 DOI: 10.1007/978-3-030-37558-4_16
31) Protective effect of curcumin towards cadmium and polycyclic aromatic hydrocarbons toxicities: The EcoNutraPrevention Project. I. Tedesco, M.Russo, S.Moccia, C. Cervellera, C.Spagnuolo, V. Carbone, P. Minasi, L.Montano, P. Verze, M. Capece, V. Mirone, A. Baraschino, M. De Rosa, M.G. Volpe, G.L. Russo. Nutrition, Metabolism & Cardiovascular Diseases, March 2020, Volume 30, Issue 3, pag. 240 DOI: https://doi.org/10.1016/j.numecd.2019.12.036
32) Discovery of the Involvement in DNA Oxidative Damage of Human Sperm Nuclear Basic Proteins of Healthy Young Men Living in Polluted Areas. G. Lettieri, G. D'Agostino, E. Mele, C. Cardito, R. Esposito, A. Cimmino, A. Giarra, M. Trifuoggi, S. Raimondo, T. Notari, F. Febbraio*, L. Montano*, M. Piscopo*. Int J Mol Sci . 2020 Jun 12;21(12):E4198. doi: 10.3390/ijms21124198
33) Semen Quality as a Potential Susceptibility Indicator to SARS-CoV-2 Insults in Polluted Areas. L. Montano*, IM. Bonapace, F. Donato, PM. Bianco, A. Guglielmino , M.Piscopo. Preprint doi: 10.20944/preprints202006.0314.v1
34) Probable role of KLK3 in menstrual cycle of young women. Mariacira Gentile, Francesca Donnarumma, Giusy Esposito, Tommaso Gentile, Ida Ferrara, Claudia Crescenzo, Mariangela Palmieri, Salvatore Raimondo & Luigi Montano. Endocrine Abstracts (2020) 70 EP388 | doi: 10.1530/endoabs.70.EP388
35) Environmental pollution affects the protamine-histone content in human sperm and changes their properties making able to promote DNA oxidative damage: the contribution of molecular investigations.M Piscopo, G Lettieri, F Febbraio, G D'Agostino, E Mele, C Cardito, L.Montano. Human Reproduction 35, 75-75 (2020)
37) Molecular Alterations in Spermatozoa of a Family Case Living in the Land of Fires—A First Look at Possible Transgenerational Effects of Pollutants. Gennaro Lettieri, Federica Marra, Claudia Moriello, Marina Prisco, Tiziana Notari, Marco Trifuoggi, Antonella Giarra, Liana Bosco, Luigi Montano*, Marina Piscopo*. Int. J. Mol. Sci. 2020, Volume 21, Issue 18, 6710.
38) Reproductive biomarkers as early indicators for assessing environmentalhealth risk. L.Montano, in Marfe,G., and Di Stefano C. Toxic Waste Management and Health Risk, BenthamScience Publishers eBook eISBN 978-981-14-5474-5 (2020) Doi: 10.2174/97898114547451200101 https.//www.eurekaselect.com/185279/chapter
39) Molecular Alterations in Spermatozoa of a Family Case Living in the Land of Fires—A First Look at Possible Transgenerational Effects of Pollutants. Gennaro Lettieri, Federica Marra, Claudia Moriello, Marina Prisco, Tiziana Notari, Marco Trifuoggi, Antonella Giarra, Liana Bosco, Luigi Montano*, Marina Piscopo*. Int. J. Mol. Sci. 2020, Volume 21, Issue 18, 6710.
40) Interdisciplinary Collaboration between Environmental Health and Clinical Experts on Cancers and Infertility Associated with Exposure to Endocrine Disruptors (2020).A. Fucic, A. Mantovani and L. Montano. https://pubs.rsc.org/en/content/ebook/978-1-78801-741-1 - https://doi.org/10.1039/9781839160738-00483
41) Effects of a lifestyle change intervention on semen quality in healthy young men living in highly polluted areas in Italy: the FASt randomized controlled trial. (2021). Montano L*, Ceretti E, Donato F, Bergamo P, Zani C, Viola GCV, Notari T, Pappalardo S, Zani D, Ubaldi S, Bollati V, Consales C, Leter G, Trifuoggi M, Amoresano A, Lorenzetti S.EurUrol Focus 2021 Feb 10;S2405-4569(21)00041-9. doi: 10.1016/j.euf.2021.01.017.
42) SARS-CoV-2 Detection in Fecal Sample from a Patient with Typical Findings of COVID-19 Pneumonia on CT but Negative to Multiple SARS-CoV-2 RT-PCR Tests on Oropharyngeal and Nasopharyngeal Swab Samples. Brogna B, Brogna C, Petrillo M, Conte AM, Benincasa G, Montano LandPiscopoM.Medicina 2021, 57(3), 290; https://doi.org/10.3390/medicina57030290
43) Microplastics in the Aquatic Environment: Occurrence, Persistence, Analysis, and Human Exposure. Ricciardi M,PirontiC, Motta O, Miele Y, Proto A andMontano L. Water 2021, 13(7), 973; https://doi.org/10.3390/w13070973
44) KLK3 as a possible novel early biomarker of environmental exposure in young women living in Polluted area (EcoFoodFertility project). Raimondo S, Gentile M,. EspositoG, Gentile T, Ferrara I, Crescenzo C, Palmieri M, Cuomo F, De Filippo S, Piscopo M, Montano L*.Preprint on Research Square April 2021 DOI: https://doi.org/10.21203/rs.3.rs-356029/v1
45) Semen analysis in “urology-naïve” patients: a chance of uroandrological screening in young male. Toso S, Ticonosco M, Rabito S, Sighinolfi MC, Ferrar Ri, Rochira V, Santi D, Trenti T, Montano L, Rocco B, Micali S. Preprint on ResearchSquare, April 2021 DOI: 10.21203/rs.3.rs-405974/v1
46) Endocrine-Disrupting Compounds: An Overview on Their Occurrence in the Aquatic Environment and Human Exposure. Pironti C, Ricciardi M, Proto A, Bianco PM,Montano L*,andMottaO*Water 2021, 13(10), 1347; https://doi.org/10.3390/w13101347
47) Blood, urine and semen Volatile Organic Compound (VOC) pattern analysis for assessing health environmental impact in highly polluted areas. Longo V,ForleoFerramosca A, Notari T, Pappalardo S, Siciliano P, Capone S, Montano L.Environmental Pollution, Available online 24 May 2021, 117410https://doi.org/10.1016/j.envpol.2021.117410
48) Semen quality as a potential susceptibility indicator to SARS-CoV-2 insults in polluted areasMontano L*., Donato F, Bianco PM, Lettieri G, Guglielmino A, Motta O, Bonapace IM*,Piscopo M*. Journal. Environmental Science and Pollution Research, may 2021 (), 1-10 DOI 10.1007/s11356-021-14579-x
49) Air pollution and COVID-19: a possible dangerous synergy for male fertility. Montano L*, Donato F, Bianco PM, Lettieri G, Guglielmino A, Motta O, Bonapace IM,* Marina Piscopo M*.Int. J. Environ. Res. Public Health 2021, 18, x. https://doi.org/10.3390/xxxxx
50) Chromatin Maturity Index (CMI) in unfixed and live spermatozoa and Aniline Blue (AB) stained as an additional evaluation parameter in idiopathic male infertility. Notari T, Piscopo M, Bosco L, Pecoraro S, Serra N, Ricciardi D, Capra G, Montano L.Human Reproduction, Volume 36, Issue Supplement_1, July 2021, deab130.073, https://doi.org/10.1093/humrep/deab130.073Published: 06 August 2021
51) Could Kallikrein-Related Serine Peptidase 3 Be an Early Biomarker of Environmental Exposure in Young Women? Raimondo S, Gentile M, Esposito G, Gentile T, Ferrara I, Crescenzo C, Palmieri M, Cuomo F, De Filippo S, Lettieri G, Piscopo M,* andMontano L 5,6*.Int. J. Environ. Res. Public Health 2021, 18, 8833. https://doi.org/10.3390/ ijerph18168833
52) Presence of p53 Protein on Spermatozoa DNA: A Novel Environmental Bio-Marker and Implications for Male Fertility. August 2021 DOI: 10.5772/intechopen.99559 In book: P53 - A Guardian of the Genome and Beyond LicenseCC BY 3.0. Salvatore Raimondo, MariaciraGentile,Tommaso Gentile and Luigi Montano
53)Microplastics in the Environment: Intake through the Food Web, Human Exposure and Toxicological Effects. Concetta Pironti, Maria Ricciardi,Oriana Motta*, Ylenia Miele, Antonio Proto and Luigi Montano*. Toxics 2021, 9(9), 224; https://doi.org/10.3390/toxics9090224